Across TCGA patient cohorts, GPAA1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPAA1-associated genes across cancer lineages are c-Met_pY1235, Annexin-1, and RBM15. Each is linked with GPAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPAA1-to-partner and partner-to-GPAA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPAA1→partner) and Y-score (partner→GPAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.109	+3.321	.004	.010	3	2
UCEC	Annexin-1 →	+0.736	+2.827	.007	.035	3	1
UCEC	RBM15 →	+0.368	+3.335	.027	.005	3	1
UCEC	Rictor_pT1135 →	-0.146	-3.321	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.223	-3.000	.011	.036	2	1
UCEC	Ku80 →	+0.443	+3.335	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

GPAA1 survival (RNA) · tumor vs normal (RNA) · all GPAA1 data types