GPA33

Across TCGA patient cohorts, GPA33 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPA33-associated genes across cancer lineages are ERK2, Tuberin_pT1462, and Caspase-8. Each is linked with GPA33 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPA33-to-partner and partner-to-GPA33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GPA33-low versus GPA33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPA33→partner) and Y-score (partner→GPA33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.234	+2.321	.003	.006	3	2
UCEC	Tuberin_pT1462 →	+0.310	+2.321	.001	.006	3	2
UCEC	Caspase-8 →	-0.213	-3.143	.040	.018	3	2
UCEC	c-Kit →	-0.240	-2.321	.012	.006	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.700	.024	.006	3	1
UCEC	A-Raf_pS299 →	-0.174	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ERK2 by GPA33 expression — UCEC

Explore this box plot interactively →