GOT1

Across TCGA patient cohorts, GOT1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,505 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GOT1-associated genes across cancer lineages are ALDH6A1, SERPINH1, and COL6A2. Each is linked with GOT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GOT1-to-partner and partner-to-GOT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GOT1 versus ALDH6A1 in CCRCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT1→partner) and Y-score (partner→GOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ALDH6A1 →	+1.303	+0.527	<.001	<.001	3	5
GBM	SERPINH1 →	-0.709	-0.492	.002	.005	3	5
OV	COL6A2 →	-1.590	-0.651	<.001	<.001	3	5
HNSC	SLC25A4 →	+0.873	+0.589	.001	<.001	3	5
OV	LAPTM5 →	-1.176	-0.352	<.001	<.001	3	5
OV	GHITM →	+0.869	+0.443	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,505 associations by consensus.

GOT1 vs ALDH6A1 — CCRCC

Explore this scatter interactively →