GOT1

Across TCGA cell cohorts, GOT1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GOT1-associated genes across cancer lineages are TBC1D21, R3HDML, and FAM205A. Each is linked with GOT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOT1-to-partner and partner-to-GOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by GOT1-low versus GOT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOT1→partner) and Y-score (partner→GOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	2
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.032	+3.614	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TBC1D21 by GOT1 expression — LARGE_INTESTINE

Explore this box plot interactively →