GOSR1

Across TCGA pan-cancer cohorts, GOSR1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GOSR1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GOSR1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GOSR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and UCEC are the cancer types where GOSR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.812	0.548	.004	34	view →
COAD	DFS	Median	All	1.000	0.884	.017	24	view →
UCEC	DFS	Median	II,III,IV	0.946	0.480	.003	20	view →
CCRCC	OS	Tertile	III,IV	0.553	0.823	.010	17	view →
LSCC	DFS	Median	II,III,IV	0.474	0.854	.001	15	view →
OV	DFS	Tertile	All	0.458	0.896	.016	8	view →
LUAD	DFS	Quartile	III,IV	0.875	0.283	.016	6	view →
PDAC	OS	Tertile	IV	0.231	0.905	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GOSR1–HNSC (DFS)

Open the HNSC breakdown →