GOSR1

Across TCGA patient cohorts, GOSR1 mutation is significantly associated with the RNA expression of many other genes, with 1,431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOSR1-associated genes across cancer lineages are RPL34P3, MIR5787, and RNU6-728P. Each is linked with GOSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOSR1-to-partner and partner-to-GOSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL34P3 grouped by GOSR1-low versus GOSR1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOSR1→partner) and Y-score (partner→GOSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL34P3 →	+0.109	+5.505	.001	.004	3	2
SKCM	MIR5787 →	+0.653	+4.513	<.001	.009	3	2
UCEC	RNU6-728P →	+0.137	+3.113	<.001	.006	3	2
UCEC	LINC02435 →	+0.507	+2.981	.002	<.001	3	2
UCEC	RNU6-1213P →	+0.218	+3.654	<.001	.001	3	2
COAD	RN7SL478P →	+0.339	+5.730	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,431 associations by consensus.

RPL34P3 by GOSR1 expression — HNSC

Explore this box plot interactively →