GOSR1

Across TCGA patient cohorts, GOSR1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOSR1-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with GOSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOSR1-to-partner and partner-to-GOSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GOSR1-low versus GOSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOSR1→partner) and Y-score (partner→GOSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.543	-3.169	.010	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.576	+2.189	.031	.034	3	2
UCEC	EGFR_pY1068 →	-0.376	-3.459	<.001	.005	3	1
UCEC	eIF4E →	+0.195	+3.169	.039	.019	3	1
UCEC	ACVRL1 →	-0.139	-2.986	.023	.035	3	1
UCEC	MEK1 →	+0.331	+2.459	.044	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PDCD4 by GOSR1 expression — UCEC

Explore this box plot interactively →