GOSR1

Across TCGA cell cohorts, GOSR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,572 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GOSR1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Double-strand break repair via alternative nonhomologous end joining, and Regulation of chromatin organization. Each is linked with GOSR1 in more than 13 cancer types. Because this analysis shows association rather than direction, both GOSR1-to-partner and partner-to-GOSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by GOSR1-low versus GOSR1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GOSR1→partner) and Y-score (partner→GOSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.172	+1.248	<.001	<.001	3	14
PANCREAS	Double-strand break repair via alternative nonhomologous end joining →	+0.122	+0.848	<.001	<.001	3	13
URINARY_TRACT	Regulation of chromatin organization →	+0.081	+0.553	<.001	<.001	3	13
KIDNEY	mRNA transcription →	+0.092	+0.747	<.001	<.001	3	13
URINARY_TRACT	Negative regulation of chromatin organization →	+0.124	+0.578	.001	.001	3	13
PANCREAS	Positive regulation of mitotic cytokinesis →	+0.135	+0.667	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

Negative regulation of chromosome condensation by GOSR1 expression — LARGE_INTESTINE

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