GORASP2

Across TCGA patient cohorts, GORASP2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GORASP2-associated genes across cancer lineages are eIF4E, INPP4B, and JNK2. Each is linked with GORASP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GORASP2-to-partner and partner-to-GORASP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GORASP2-low versus GORASP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GORASP2→partner) and Y-score (partner→GORASP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.166	+2.000	.026	.030	2	3
UCEC	INPP4B →	-0.321	-1.678	.005	.021	3	2
UCEC	JNK2 →	+0.161	+1.362	.021	.037	3	2
UCEC	mTOR_pS2448 →	-0.122	-2.302	.021	.005	3	2
UCEC	Rad50 →	-0.239	-1.986	.005	.029	3	2
UCEC	ASNS →	+0.431	+1.807	<.001	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by GORASP2 expression — UCEC

Explore this box plot interactively →