GOPC

Across TCGA pan-cancer cohorts, GOPC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GOPC data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GOPC mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GOPC expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, PDAC, and COAD are the cancer types where GOPC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.811	0.276	.001	53	view →
PDAC	DFS	Tertile	III,IV	0.219	0.974	.001	34	view →
COAD	DFS	Median	All	1.000	0.885	.018	24	view →
HNSC	DFS	Quartile	III,IV	0.447	0.799	.002	11	view →
CCRCC	DFS	Tertile	IV	0.948	0.207	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GOPC–LUAD (OS)

Open the LUAD breakdown →