GOPC

Across TCGA patient cohorts, GOPC protein abundance is significantly associated with the RNA expression of many other genes, with 8,734 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GOPC-associated genes across cancer lineages are DCBLD1, COL10A1, and LINC02544. Each is linked with GOPC in more than 5 cancer types. Because this analysis shows association rather than direction, both GOPC-to-partner and partner-to-GOPC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GOPC versus DCBLD1 in HNSC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOPC→partner) and Y-score (partner→GOPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DCBLD1 →	+0.912	+0.288	<.001	<.001	3	6
BRCA	COL10A1 →	+1.630	+0.302	<.001	<.001	3	5
PDAC	LINC02544 →	+1.389	+0.355	<.001	<.001	3	5
BRCA	NKX3-2 →	+0.841	+0.437	<.001	<.001	3	4
PDAC	COL12A1 →	+1.263	+0.268	<.001	<.001	3	4
PDAC	LOX →	+0.893	+0.253	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,734 associations by consensus.

GOPC vs DCBLD1 — HNSC

Explore this scatter interactively →