GOPC

Across TCGA patient cohorts, GOPC mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOPC-associated genes across cancer lineages are SUGT1P4, PABPC1P12, and OR5L1. Each is linked with GOPC in more than 1 cancer types. Because this analysis shows association rather than direction, both GOPC-to-partner and partner-to-GOPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUGT1P4 grouped by GOPC-low versus GOPC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOPC→partner) and Y-score (partner→GOPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SUGT1P4 →	+0.230	+4.328	<.001	.007	3	2
BLCA	PABPC1P12 →	+0.070	+4.973	<.001	.009	3	2
BRCA	OR5L1 →	+0.039	+7.731	<.001	.009	3	1
CESC	CYP11B2 →	+0.031	+5.103	<.001	.008	3	1
CESC	RNU6-545P →	+0.321	+6.569	<.001	.001	3	1
CESC	RNU6-338P →	+0.422	+5.812	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

SUGT1P4 by GOPC expression — SKCM

Explore this box plot interactively →