GOPC

Across TCGA patient cohorts, GOPC mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOPC-associated genes across cancer lineages are PAI-1, ATM, and EGFR_pY1068. Each is linked with GOPC in more than 1 cancer types. Because this analysis shows association rather than direction, both GOPC-to-partner and partner-to-GOPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by GOPC-low versus GOPC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOPC→partner) and Y-score (partner→GOPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.371	+2.584	.013	.010	3	2
UCEC	ATM →	-0.568	-3.584	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.245	-3.321	.025	.010	3	1
UCEC	MEK1 →	+0.339	+2.115	.034	.019	3	1
UCEC	Notch1 →	+0.221	+2.009	<.001	.017	3	1
UCEC	p21 →	+0.221	+2.335	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PAI-1 by GOPC expression — UCEC

Explore this box plot interactively →