GOPC

Across TCGA cell cohorts, GOPC mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GOPC-associated genes across cancer lineages are DAZ2, ECE2, and PPDPFL. Each is linked with GOPC in more than 1 cancer types. Because this analysis shows association rather than direction, both GOPC-to-partner and partner-to-GOPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by GOPC-low versus GOPC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOPC→partner) and Y-score (partner→GOPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DAZ2 →	+0.235	+5.228	<.001	.005	3	2
LARGE_INTESTINE	ECE2 →	+0.205	+2.791	.004	.005	3	1
LARGE_INTESTINE	PPDPFL →	+0.033	+3.632	<.001	<.001	3	1
LARGE_INTESTINE	FAM153B →	+0.549	+3.648	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

DAZ2 by GOPC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →