GOPC

Across TCGA cell cohorts, GOPC mutation is significantly associated with the mutation status of many other genes, with 3,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GOPC-associated genes across cancer lineages are RALGAPA2, WDR55, and PLEKHA7. Each is linked with GOPC in more than 3 cancer types. Because this analysis shows association rather than direction, both GOPC-to-partner and partner-to-GOPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RALGAPA2 grouped by GOPC-low versus GOPC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOPC→partner) and Y-score (partner→GOPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RALGAPA2 →	+3.430	+4.545	<.001	<.001	1	4
KIDNEY	WDR55 →	+5.000	+5.000	.006	.006	1	3
KIDNEY	PLEKHA7 →	+5.000	+5.000	.006	.006	1	3
LUNG_NSCLC_LUAD	FARP1 →	+5.339	+4.772	.004	.004	1	3
LUNG_NSCLC_LUAD	EFCAB5 →	+4.339	+4.339	.009	.009	1	3
BLOOD_Leukemia	IFIH1 →	+3.108	+3.108	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

RALGAPA2 by GOPC expression — BLOOD_Leukemia

Explore this box plot interactively →