GON7

Across TCGA cell cohorts, GON7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,777 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GON7-associated GO terms across cancer lineages are tRNA threonylcarbamoyladenosine modification, Maintenance of translational fidelity, and Positive regulation of ERK1 and ERK2 cascade. Each is linked with GON7 in more than 16 cancer types. Because this analysis shows association rather than direction, both GON7-to-partner and partner-to-GON7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA threonylcarbamoyladenosine modification grouped by GON7-low versus GON7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GON7→partner) and Y-score (partner→GON7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	tRNA threonylcarbamoyladenosine modification →	+0.201	+1.142	<.001	<.001	3	17
LUNG_SCLC	Maintenance of translational fidelity →	+0.113	+0.588	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Positive regulation of ERK1 and ERK2 cascade →	-0.073	-0.992	<.001	.001	3	10
OVARY	Regulation of DNA damage checkpoint →	+0.105	+0.708	<.001	.001	3	10
LARGE_INTESTINE	DAMP biosynthetic process →	+0.109	+0.849	<.001	<.001	3	10
CNS	Double-strand break repair →	+0.048	+0.748	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,777 associations by consensus.

tRNA threonylcarbamoyladenosine modification by GON7 expression — BONE

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