GOLPH3L

Across TCGA pan-cancer cohorts, GOLPH3L mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GOLPH3L data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GOLPH3L mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GOLPH3L expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and LUAD are the cancer types where GOLPH3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.645	0.358	<.001	79	view →
COAD	DFS	Median	II,III,IV	1.000	0.882	.022	42	view →
LUAD	OS	Median	III,IV	0.823	0.289	<.001	34	view →
LSCC	OS	Median	All	0.695	0.888	.011	6	view →
CCRCC	DFS	Quartile	III,IV	0.329	0.807	.025	2	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GOLPH3L–PDAC (OS)

Open the PDAC breakdown →