GOLPH3L

Across TCGA pan-cancer cohorts, GOLPH3L mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GOLPH3L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GOLPH3L mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GOLPH3L is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where GOLPH3L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GOLPH3L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.935	<.001	9	view →
HNSC	Male	II,III,IV	−0.541	<.001	8	view →
LSCC	Male	III,IV	+0.395	<.001	8	view →
CCRCC	Male	III,IV	+0.259	<.001	8	view →
PDAC	Female	II,III,IV	−0.694	<.001	6	view →
OV	All	All	+0.392	.025	2	view →
COAD	Female	IV	−0.877	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GOLPH3L–LUAD

Open the LUAD breakdown →