GOLPH3L

Across TCGA patient cohorts, GOLPH3L mutation is significantly associated with the RNA expression of many other genes, with 2,477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLPH3L-associated genes across cancer lineages are ATF4P2, GNAT2, and IGHV3OR16-6. Each is linked with GOLPH3L in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLPH3L-to-partner and partner-to-GOLPH3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P2 grouped by GOLPH3L-low versus GOLPH3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLPH3L→partner) and Y-score (partner→GOLPH3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P2 →	+0.030	+2.221	<.001	.008	3	2
SKCM	GNAT2 →	+0.034	+4.034	<.001	.004	3	2
UCEC	IGHV3OR16-6 →	+0.393	+1.912	.008	.009	3	1
UCEC	MIR98 →	+0.246	+2.423	.001	.004	3	1
UCEC	LINC02084 →	+0.607	+2.617	<.001	.005	3	1
UCEC	H2BC14 →	+0.440	+2.765	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,477 associations by consensus.

ATF4P2 by GOLPH3L expression — UCEC

Explore this box plot interactively →