GOLPH3

Across TCGA pan-cancer cohorts, GOLPH3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GOLPH3 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GOLPH3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GOLPH3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where GOLPH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.483	0.894	<.001	52	view →
CCRCC	OS	Median	All	0.647	1.000	.005	12	view →
HNSC	OS	Median	IV	0.613	0.830	.022	8	view →
PDAC	OS	Tertile	II,III,IV	0.921	0.750	.014	7	view →
UCEC	DFS	Quartile	III,IV	1.000	0.388	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GOLPH3–LSCC (DFS)

Open the LSCC breakdown →