GOLPH3

Across TCGA patient cohorts, GOLPH3 mutation is significantly associated with the RNA expression of many other genes, with 1,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLPH3-associated genes across cancer lineages are SNORD115-41, RNA5SP413, and RNA5SP205. Each is linked with GOLPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLPH3-to-partner and partner-to-GOLPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-41 grouped by GOLPH3-low versus GOLPH3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLPH3→partner) and Y-score (partner→GOLPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNORD115-41 →	+0.236	+7.930	<.001	.008	3	2
LUAD	RNA5SP413 →	+0.188	+7.930	<.001	.008	3	2
UCEC	RNA5SP205 →	+0.161	+2.460	<.001	.007	3	2
COAD	SNORD3P1 →	+0.337	+5.435	.001	.005	3	1
COAD	RNU6-1029P →	+0.576	+5.212	<.001	.007	3	1
COAD	MIR30B →	+0.493	+6.122	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,786 associations by consensus.

SNORD115-41 by GOLPH3 expression — LUAD

Explore this box plot interactively →