GOLPH3

Across TCGA patient cohorts, GOLPH3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLPH3-associated genes across cancer lineages are FOXO3a_pS318_S321, A-Raf_pS299, and ERK2. Each is linked with GOLPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLPH3-to-partner and partner-to-GOLPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by GOLPH3-low versus GOLPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLPH3→partner) and Y-score (partner→GOLPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.138	-2.312	.006	.005	3	2
UCEC	A-Raf_pS299 →	-0.114	-2.807	.017	.003	3	1
UCEC	ERK2 →	+0.235	+2.000	.002	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.000	.005	.030	3	1
UCEC	MEK1 →	+0.533	+3.087	<.001	<.001	3	1
UCEC	MSH2 →	-0.377	-2.433	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FOXO3a_pS318_S321 by GOLPH3 expression — UCEC

Explore this box plot interactively →