GOLM1

Across TCGA patient cohorts, GOLM1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLM1-associated genes across cancer lineages are JNK_pT183_Y185, p62 Lck ligand, and STAT3_pY705. Each is linked with GOLM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLM1-to-partner and partner-to-GOLM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GOLM1-low versus GOLM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLM1→partner) and Y-score (partner→GOLM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.193	-1.893	.004	.016	3	2
UCEC	p62 Lck ligand →	+0.344	+2.469	.008	.010	3	2
UCEC	STAT3_pY705 →	-0.306	-2.574	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.597	+2.321	.008	.033	3	2
UCEC	Cyclin-E2 →	+0.147	+2.999	.030	.035	3	2
UCEC	14-3-3_beta →	-0.092	-2.295	.023	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by GOLM1 expression — UCEC

Explore this box plot interactively →