GOLIM4

Across TCGA patient cohorts, GOLIM4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLIM4-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and JNK_pT183_Y185. Each is linked with GOLIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLIM4-to-partner and partner-to-GOLIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by GOLIM4-low versus GOLIM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLIM4→partner) and Y-score (partner→GOLIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.130	-2.321	.005	.034	3	2
UCEC	INPP4B →	-0.258	-2.321	.042	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.222	-3.700	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.142	-1.980	.015	.030	3	2
UCEC	p70-S6K_pT389 →	-0.230	-2.459	.002	.018	3	2
UCEC	PCNA →	+0.297	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

A-Raf_pS299 by GOLIM4 expression — UCEC

Explore this box plot interactively →