Across TCGA pan-cancer cohorts, GOLGA6L6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of GOLGA6L6’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where GOLGA6L6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GOLGA6L6 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
LUSC and STAD are the cancer types where GOLGA6L6 tumor–normal differential expression is most reproducible.