GOLGA5

Across TCGA patient cohorts, GOLGA5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLGA5-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Rad50, and ATM. Each is linked with GOLGA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GOLGA5-to-partner and partner-to-GOLGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by GOLGA5-low versus GOLGA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLGA5→partner) and Y-score (partner→GOLGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.461	-2.321	.001	<.001	3	2
UCEC	Rad50 →	-0.212	-2.794	.006	.002	3	2
UCEC	ATM →	-0.516	-2.893	<.001	.001	3	2
UCEC	eIF4E →	+0.171	+1.716	.012	.003	3	1
UCEC	eIF4G →	+0.229	+1.906	.022	.015	3	1
UCEC	FoxM1 →	+0.207	+1.594	.013	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p38-MAPK_pT180_Y182 by GOLGA5 expression — UCEC

Explore this box plot interactively →