GOLGA3

Across TCGA patient cohorts, GOLGA3 mutation is significantly associated with the RNA expression of many other genes, with 4,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GOLGA3-associated genes across cancer lineages are POLE3, COQ3, and FAM136A. Each is linked with GOLGA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GOLGA3-to-partner and partner-to-GOLGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE3 grouped by GOLGA3-low versus GOLGA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GOLGA3→partner) and Y-score (partner→GOLGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE3 →	+0.423	+2.178	<.001	<.001	3	5
SKCM	COQ3 →	+0.454	+2.434	.008	.001	3	5
SKCM	FAM136A →	+0.415	+3.497	.002	.002	3	5
COAD	PSMD9 →	+0.406	+3.512	<.001	.002	3	4
COAD	CKS2 →	+0.536	+3.472	.002	.002	3	4
COAD	NUSAP1 →	+0.669	+2.807	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,114 associations by consensus.

POLE3 by GOLGA3 expression — UCEC

Explore this box plot interactively →