GNS

Across TCGA pan-cancer cohorts, GNS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GNS data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GNS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNS expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where GNS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.886	1.000	.020	24	view →
HNSC	DFS	Quartile	IV	0.542	0.855	.011	14	view →
CCRCC	DFS	Quartile	III,IV	0.368	0.731	.013	12	view →
LUAD	DFS	Median	II,III,IV	0.686	0.970	.004	10	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
GBM	DFS	Quartile	All	0.702	0.867	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GNS–COAD (DFS)

Open the COAD breakdown →