Across TCGA pan-cancer cohorts, GNRHR2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GNRHR2 data layer.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GNRHR2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNRHR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.
LIHC, ACC, and HNSC are the cancer types where GNRHR2 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.