GNRHR

Across TCGA pan-cancer cohorts, GNRHR Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GNRHR data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GNRHR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GNRHR expression acts as an unfavorable survival marker.

LUAD, UCS, and GBM are the cancer types where GNRHR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.083	0.680	<.001	12	view →
UCS	DFS	Median	All	0.136	0.523	.034	6	view →
GBM	OS	Median	All	0.121	0.415	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GNRHR–LUAD (OS)

Open the LUAD breakdown →