GNRH2

Across TCGA cell cohorts, GNRH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,797 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GNRH2-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Negative regulation of mRNA splicing, via spliceosome, and Establishment of mitotic spindle localization. Each is linked with GNRH2 in more than 10 cancer types. Because this analysis shows association rather than direction, both GNRH2-to-partner and partner-to-GNRH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by GNRH2-low versus GNRH2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNRH2→partner) and Y-score (partner→GNRH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.086	+0.177	<.001	.007	3	11
OVARY	Negative regulation of mRNA splicing, via spliceosome →	+0.101	+0.329	<.001	<.001	3	10
BONE	Establishment of mitotic spindle localization →	+0.101	+0.156	.002	.001	2	10
OVARY	Negative regulation of mRNA processing →	+0.097	+0.338	<.001	<.001	3	9
CNS	Regulation of protein localization to endoplasmic reticulum →	+0.100	+0.305	<.001	.002	2	10
CNS	Establishment of spindle localization →	+0.065	+0.219	<.001	.002	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,797 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by GNRH2 expression — OVARY

Explore this box plot interactively →