GNPTG

Across TCGA patient cohorts, GNPTG mutation is significantly associated with the RNA expression of many other genes, with 2,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPTG-associated genes across cancer lineages are RNA5SP418, RNU6-275P, and RNA5SP59. Each is linked with GNPTG in more than 2 cancer types. Because this analysis shows association rather than direction, both GNPTG-to-partner and partner-to-GNPTG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP418 grouped by GNPTG-low versus GNPTG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPTG→partner) and Y-score (partner→GNPTG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP418 →	+0.735	+2.085	<.001	.004	3	3
CESC	RNU6-275P →	+0.327	+5.569	<.001	.002	3	2
BRCA	RNA5SP59 →	+0.283	+8.055	<.001	.007	3	2
UCEC	MIR6803 →	+0.144	+4.390	<.001	.003	3	2
COAD	RPL13AP →	+0.220	+3.988	.002	.003	3	2
COAD	RNU6-709P →	+0.464	+5.142	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,351 associations by consensus.

RNA5SP418 by GNPTG expression — UCEC

Explore this box plot interactively →