GNPTG

Across TCGA cell cohorts, GNPTG mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNPTG-associated genes across cancer lineages are SEC14L3, ZAN, and SAXO1. Each is linked with GNPTG in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPTG-to-partner and partner-to-GNPTG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC14L3 grouped by GNPTG-low versus GNPTG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPTG→partner) and Y-score (partner→GNPTG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEC14L3 →	+0.030	+3.994	<.001	.002	3	1
LARGE_INTESTINE	ZAN →	+0.017	+3.882	<.001	.001	3	1
LARGE_INTESTINE	SAXO1 →	+0.046	+3.556	.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1
LARGE_INTESTINE	RNASE8 →	+0.027	+3.345	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SEC14L3 by GNPTG expression — LARGE_INTESTINE

Explore this box plot interactively →