GNPTAB

Across TCGA pan-cancer cohorts, GNPTAB mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GNPTAB’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GNPTAB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GNPTAB is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where GNPTAB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNPTAB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	III,IV	+0.393	<.001	9	view →
LUAD	All	III,IV	+0.236	<.001	8	view →
LSCC	Male	All	+0.208	<.001	7	view →
COAD	All	All	−0.339	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GNPTAB–CCRCC

Open the CCRCC breakdown →