GNPDA2

Across TCGA patient cohorts, GNPDA2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPDA2-associated genes across cancer lineages are Annexin-1, eIF4E, and FoxM1. Each is linked with GNPDA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPDA2-to-partner and partner-to-GNPDA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GNPDA2-low versus GNPDA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPDA2→partner) and Y-score (partner→GNPDA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.470	+1.604	.020	.041	3	2
UCEC	eIF4E →	+0.234	+3.807	.003	<.001	3	1
UCEC	FoxM1 →	+0.294	+2.087	.003	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.121	-2.105	.011	.017	3	1
UCEC	JNK2 →	+0.219	+2.594	.004	.006	3	1
UCEC	Ku80 →	+0.312	+2.916	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Annexin-1 by GNPDA2 expression — UCEC

Explore this box plot interactively →