GNPAT

Across TCGA patient cohorts, GNPAT protein abundance is significantly associated with the RNA expression of many other genes, with 8,395 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GNPAT-associated genes across cancer lineages are PYCR2, INTS7, and RNF187. Each is linked with GNPAT in more than 6 cancer types. Because this analysis shows association rather than direction, both GNPAT-to-partner and partner-to-GNPAT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNPAT versus PYCR2 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPAT→partner) and Y-score (partner→GNPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PYCR2 →	+0.541	+0.250	<.001	<.001	3	7
HNSC	INTS7 →	+0.442	+0.243	.003	<.001	3	6
LSCC	RNF187 →	+0.514	+0.219	<.001	<.001	3	6
LUAD	CD46 →	+0.622	+0.487	<.001	<.001	3	5
UCEC	UHMK1 →	+0.392	+0.319	.005	<.001	3	5
UCEC	ADIPOR1 →	+0.508	+0.444	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,395 associations by consensus.

GNPAT vs PYCR2 — LSCC

Explore this scatter interactively →