GNPAT

Across TCGA patient cohorts, GNPAT mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNPAT-associated genes across cancer lineages are ATM, Notch1, and p21. Each is linked with GNPAT in more than 2 cancer types. Because this analysis shows association rather than direction, both GNPAT-to-partner and partner-to-GNPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GNPAT-low versus GNPAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPAT→partner) and Y-score (partner→GNPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.450	-2.201	.003	<.001	3	3
UCEC	Notch1 →	+0.127	+1.321	.007	.029	3	2
UCEC	p21 →	+0.179	+2.415	.005	.003	3	2
UCEC	PCNA →	+0.207	+2.906	.004	.001	3	2
UCEC	Rab25 →	-0.420	-2.584	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.349	-1.990	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by GNPAT expression — UCEC

Explore this box plot interactively →