GNPAT

Across TCGA cell cohorts, GNPAT mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GNPAT-associated genes across cancer lineages are TBR1, TMSB4Y, and ACSM6. Each is linked with GNPAT in more than 1 cancer types. Because this analysis shows association rather than direction, both GNPAT-to-partner and partner-to-GNPAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by GNPAT-low versus GNPAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNPAT→partner) and Y-score (partner→GNPAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBR1 →	+0.051	+3.555	<.001	.003	3	1
LARGE_INTESTINE	TMSB4Y →	+1.103	+3.374	.001	.005	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.000	.001	.005	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	FTHL17 →	+0.180	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	S100G →	+0.058	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TBR1 by GNPAT expression — LARGE_INTESTINE

Explore this box plot interactively →