GNL3

Across TCGA patient cohorts, GNL3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNL3-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_beta, and EGFR_pY1068. Each is linked with GNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNL3-to-partner and partner-to-GNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GNL3-low versus GNL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL3→partner) and Y-score (partner→GNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.143	-1.664	.027	.023	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.010	.009	3	1
UCEC	EGFR_pY1068 →	-0.215	-2.000	.025	.030	3	1
UCEC	eIF4E →	+0.185	+3.321	.022	.010	3	1
UCEC	A-Raf_pS299 →	-0.096	-2.000	.036	.030	3	1
UCEC	Gab2 →	+0.293	+2.087	.032	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK_pT183_Y185 by GNL3 expression — UCEC

Explore this box plot interactively →