GNL3

Across TCGA cell cohorts, GNL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,398 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GNL3-associated GO terms across cancer lineages are 'de novo' IMP biosynthetic process, Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Nucleosome disassembly. Each is linked with GNL3 in more than 17 cancer types. Because this analysis shows association rather than direction, both GNL3-to-partner and partner-to-GNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' IMP biosynthetic process grouped by GNL3-low versus GNL3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL3→partner) and Y-score (partner→GNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	'de novo' IMP biosynthetic process →	+0.172	+0.710	<.001	.002	3	18
BONE	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.122	+0.777	<.001	<.001	3	17
KIDNEY	Nucleosome disassembly →	+0.124	+0.583	<.001	.003	3	17
LUNG_SCLC	Maturation of SSU-rRNA →	+0.134	+0.907	<.001	<.001	3	16
BONE	Ribosomal small subunit biogenesis →	+0.118	+0.796	<.001	<.001	3	16
CNS	DNA-templated transcription elongation →	+0.071	+0.689	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,398 associations by consensus.

'de novo' IMP biosynthetic process by GNL3 expression — LUNG_SCLC

Explore this box plot interactively →