GNL3

Across TCGA cell cohorts, GNL3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNL3-associated genes across cancer lineages are FOXI2, KRT25, and AVP. Each is linked with GNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNL3-to-partner and partner-to-GNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXI2 grouped by GNL3-low versus GNL3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL3→partner) and Y-score (partner→GNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FOXI2 →	+0.379	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRT25 →	+0.537	+4.867	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ODF3 →	+0.058	+3.836	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FOXI2 by GNL3 expression — BLOOD_Lymphoma

Explore this box plot interactively →