GNL2

Across TCGA pan-cancer cohorts, GNL2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GNL2 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GNL2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GNL2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where GNL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.672	0.972	<.001	53	view →
LUAD	DFS	Median	III,IV	0.805	0.247	.001	23	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.870	.009	15	view →
PDAC	OS	Median	III,IV	0.271	0.587	.001	14	view →
HNSC	DFS	Tertile	III,IV	0.731	0.937	.012	11	view →
UCEC	DFS	Tertile	All	1.000	0.909	.046	2	view →
GBM	OS	Tertile	All	0.550	0.208	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GNL2–CCRCC (OS)

Open the CCRCC breakdown →