Across TCGA pan-cancer cohorts, GNL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNL1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GNL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where GNL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.788	0.424	.003	26	view →
UCEC	OS	Median	All	0.904	1.000	.008	24	view →
LSCC	OS	Tertile	All	0.897	0.685	.020	15	view →
HNSC	OS	Median	All	0.380	1.000	.008	14	view →
LUAD	OS	Quartile	II,III,IV	0.243	0.687	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GNL1 tumor-vs-normal RNA expression · all GNL1 data types