Across TCGA patient cohorts, GNL1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNL1-associated genes across cancer lineages are FoxM1, Acetyl-a-Tubulin-Lys40, and PDCD4. Each is linked with GNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNL1-to-partner and partner-to-GNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNL1→partner) and Y-score (partner→GNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.259	+2.321	.046	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.600	+2.321	.018	.035	3	1
UCEC	PDCD4 →	-0.594	-3.459	.011	.005	3	1
UCEC	STAT3_pY705 →	-0.457	-3.459	<.001	.005	3	1
UCEC	Bcl-2 →	-0.351	-2.295	.044	.036	3	1
UCEC	ACC_pS79 →	+0.534	+2.817	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

GNL1 survival (RNA) · tumor vs normal (RNA) · all GNL1 data types