GNG5

Across TCGA pan-cancer cohorts, GNG5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GNG5 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GNG5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNG5 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, COAD, and CCRCC are the cancer types where GNG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.711	0.970	.011	30	view →
COAD	DFS	Median	II,III,IV	0.912	1.000	.013	24	view →
CCRCC	OS	Median	II,III,IV	0.485	1.000	.010	8	view →
PDAC	OS	Median	III,IV	0.255	0.609	.018	5	view →
LUAD	OS	Median	III,IV	0.323	0.779	.024	4	view →
HNSC	DFS	Median	IV	1.000	0.927	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GNG5–UCEC (DFS)

Open the UCEC breakdown →