GNG4

Across TCGA pan-cancer cohorts, GNG4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GNG4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher GNG4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNG4 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, UCEC, and HNSC are the cancer types where GNG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.920	0.621	<.001	26	view →
UCEC	DFS	Median	All	0.858	0.970	.008	22	view →
HNSC	DFS	Tertile	All	0.709	0.917	.004	13	view →
LUAD	OS	Quartile	All	0.520	0.963	.020	7	view →
PDAC	DFS	Quartile	All	0.177	0.604	.034	6	view →
LSCC	OS	Tertile	II,III,IV	0.954	0.712	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GNG4–GBM (DFS)

Open the GBM breakdown →