GNG4

Across TCGA patient cohorts, GNG4 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,999 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNG4-associated proteins across cancer lineages are MSH2, MSH6, and MUC1. Each is linked with GNG4 in more than 4 cancer types. Because this analysis shows association rather than direction, both GNG4-to-partner and partner-to-GNG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNG4 versus MSH2 in GBM, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG4→partner) and Y-score (partner→GNG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSH2 →	+0.616	+1.590	<.001	<.001	3	5
LSCC	MSH6 →	+0.495	+0.994	<.001	<.001	3	5
COAD	MUC1 →	-0.980	-1.782	<.001	<.001	3	5
LSCC	ORC3 →	+0.309	+1.070	.002	.001	3	5
GBM	PBK →	+0.686	+1.428	<.001	<.001	3	5
BRCA	PHF10 →	+0.320	+1.729	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,999 associations by consensus.

GNG4 vs MSH2 — GBM

Explore this scatter interactively →