GNG4

Across TCGA patient cohorts, GNG4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG4-associated genes across cancer lineages are Ku80, mTOR, and NDRG1_pT346. Each is linked with GNG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG4-to-partner and partner-to-GNG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GNG4-low versus GNG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG4→partner) and Y-score (partner→GNG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.291	+2.817	.024	.036	3	1
UCEC	mTOR →	-0.216	-3.169	.014	.020	3	1
UCEC	NDRG1_pT346 →	-0.559	-3.169	.038	.020	3	1
UCEC	Paxillin →	+0.412	+3.009	.003	.019	3	1
UCEC	YB-1_pS102 →	-0.221	-3.169	.030	.020	3	1
UCEC	Cyclin-B1 →	+0.628	+3.169	.041	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by GNG4 expression — UCEC

Explore this box plot interactively →