GNG12

Across TCGA pan-cancer cohorts, GNG12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNG12 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GNG12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNG12 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where GNG12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.555	0.890	<.001	57	view →
PDAC	OS	Quartile	III,IV	0.965	0.450	.016	8	view →
HNSC	OS	Median	All	1.000	0.958	.020	7	view →
LUAD	DFS	Quartile	All	0.812	0.453	.030	4	view →
LSCC	DFS	Quartile	All	0.637	0.851	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNG12–CCRCC (DFS)

Open the CCRCC breakdown →