GNG12

Across TCGA patient cohorts, GNG12 mutation is significantly associated with the RNA expression of many other genes, with 722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNG12-associated genes across cancer lineages are NDUFAF5, PXMP4, and ACOD1. Each is linked with GNG12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNG12-to-partner and partner-to-GNG12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by GNG12-low versus GNG12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNG12→partner) and Y-score (partner→GNG12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.518	+3.534	<.001	.002	3	1
UCEC	PXMP4 →	+1.044	+3.354	<.001	.005	3	1
UCEC	ACOD1 →	+0.166	+3.885	.001	<.001	3	1
UCEC	MON1B →	+0.651	+3.202	<.001	.009	3	1
UCEC	AAGAB →	+0.691	+3.502	<.001	.002	3	1
UCEC	PLEKHJ1 →	+1.027	+3.470	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 722 associations by consensus.

NDUFAF5 by GNG12 expression — UCEC

Explore this box plot interactively →